Desktop Application Logins

Is it possible to use 1Password to login to desktop applications that could use a user's AD credentials or may have non-AD integrated credentials?  If so, how would you automate to autofill or auto login to these applications?

Tested using the drag and drop method for an application that uses <domainname>\<username> for logging in, but haven't figured out how or if this can be automated, and it really isn't easier or faster than typing in your username/password by the time you search for the application in the 1Password desktop app and then drag/drop to the required fields.