Ctrl/Cmd-Shift-X doesn't work when 1Password is locked

I found the problem and solution for me.

I recently upgraded to an AMD Radeon 9800X3D processor and in doing so the system by default installed a piece of software called "AMD Software: Adrenalin Edition".

If you open up that software and click on the gear settings icon, then click on hotkeys. Now disable hotkeys. Your 1password shortcut will start working again.

The funny thing is that in the software it lists all of the hotkeys that it uses, and ctrl + shift + x is NOT one of them. But for some reason disabling this feature resolves the issue regardless.

My best guess is that this software is reading for hotkeys and then not correctly bubbling up any keys that it does not have an event handler for.

Anyway, Hope this helps.