Update

For the poor souls that are coming here to get help

To make it work I had to:

• right click on the extension icon
• choose "Settings"
• Find a "Sign in to another account" button at the bottom of a long page of settings
• Click it
• Find out what the obscure onscreen instructions actually meant
• Type URL, email address, secret code, password, the weight of my soul, and my age in milliseconds, into a form inside the desktop app that somehow automatically opened and I don't know what would've happened hadn't I previously installed it

And now it works also on my second profile.

Boy, you need to do some UX testing.

Anyways, all is good now.

Original

I'm having similar problems.

I've just moved from LastPass after the recent critical breach, and I have already stumbled upon a UX blocker.
Everything that I'm about to describe worked flawlessly from my day 1 (years ago) with LastPass.

I have Chrome Profile A, where I installed the browser extension and it works.
I have Chrome Profile B, where I installed the browser extension and it doesn't do anything. Moreso, when using profile B, the extension icon has a little lock icon on it, and when I click on the extension icon all I get is a popover window with a big blue "Open 1Password" button which does absolutely nothing when clicked.

I already tried to close and reopen the browser, and the profiles, and uninstall and reinstall the extension.

All of this I discovered because I just installed 1Password and I was going to change the passwords I already imported from LastPass.
Please tell me that this 1.5yrs old issue will be taken seriously and I won't have to fumble between browser windows, unable to use autofill, for the rest of my time with 1Password.