Windows app will not connect--always has the red cloud with strikethrough, attempt to reconnect fail

Thanks for the follow, @thurford,

You're right, working remotely does make it difficult to test in safe mode. This would have been the easiest way to confirm if some other software is interfering.

Temporarily uninstalling ESET is also and option. In the case of either whitelisting or uninstalling, restarting the machine afterwards would be required. Security software can continue to lockdown the 1Password directory until a reboot is complete.

I hope this bit of extra information is helpful. Do let us know how you make out, or if we can be of further assistance.