1password locks after a few hours even if the my setting is Never

Hello again Giuseppe123,

Thanks for your reply and letting us know that Lock when computer locks is turned off. We can rule out that if the device sleep during the idle time, 1Password for Windows is not locking due to this setting.

I seldom use the app, most of the times I only use the extension in Chrome (1Password – Password Manager 2.14.1).

The 1Password for Windows desktop app and browser extension can be integrated so that the extension will rely on current lock state of the desktop app. Could you confirm this setting is enabled?
1. Open your browser, right-click the 1Password icon in the address bar, and choose Settings.
1. Under the General heading, enable Integrate with 1Password app as needed.

If that setting was not enabled, does this help and allow both the app and extension to stay unlocked for the duration you've set in the app itself?
* Manage auto-lock in the 1Password apps

Let us know how this goes!